Below is a list of just some of the more relevant studies on Age Guard’s powerful supplements. 

Nicotinamide Mononucleotide (NMN)

·        Taking 600 mg of NMN significantly increased blood NAD⁺ levels, improved physical performance (measured by a six-minute walking test), and maintained biological age over 60 days in healthy middle-aged adults:  NMN Significantly Boosts NAD+ Levels and Enhances Physical Function in Latest Human Trial

·        Taking 600 mg of NMN daily improved endurance, boosted NAD⁺ levels, and enhanced self-reported health and well-being in adults aged 40–65: NMN Significantly Boosts NAD+ Levels and Enhances Physical Function in Latest Human Trial

·        Concise summary of the clinical trial comparing 300 mg, 600 mg, and 900 mg doses, all of which showed significant NAD⁺ increases, with 600 mg being particularly effective. New Insights into NMN Supplementation: A Comprehensive Clinical Study on Cellular Health and NAD+ Levels - NMN Canada : Canada's Most Reliable Research on NMN Supplementation.

·        A breakdown of the same 600 mg NMN study, highlighting a 470% increase in NAD⁺ levels and a 50% improvement in walking distance over 60 days: 600 mg of NMN Improves Endurance In People Aged 40-65 – Renue By Science Australia

Trimethylglycine (TMG)

·        TMG supplementation improved muscle endurance and power output in resistance-trained men: https://doi.org/10.1079/BJN2003927

·        TMG lowers homocysteine levels: The use of betaine in the treatment of elevated homocysteine - ScienceDirect

·        TMG delays age-related muscle loss: Betaine delays age-related muscle loss by mitigating Mss51-induced impairment in mitochondrial respiration via Yin Yang1 - PubMed https://doi.org/10.1016/j.mehy.2005.03.037

·        TMG supresses proinflammatory signalling during aging: Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases - PubMed

Spermidine

·        Spermidine supplementation improves memory in older adults (2021) – EBioMedicine – https://doi.org/10.1016/j.ebiom.2021.103702

·        Dietary spermidine intake correlates with lower mortality (2018) – Nature Medicine – https://doi.org/10.1038/s41591-018-0105-6

·        Spermidine enhances cognitive performance in humans (2021) – Neurobiology of Aging – https://doi.org/10.1016/j.neurobiolaging.2020.12.021

·        Spermidine reduces blood pressure in older adults (2021) – Scientific Reports – https://doi.org/10.1038/s41598-021-85826-5

·        Spermidine modulates inflammatory markers in humans (2021) – Journal of Nutritional Biochemistry – https://doi.org/10.1016/j.jnutbio.2021.108855

Hyaluronic Acid

·        Oral HA improves skin hydration and elasticity in elderly women (2016) – Int J Cosmetic Science – https://doi.org/10.1111/ics.12284

·        HA ingestion benefits dry skin in middle-aged adults (2021) – Int J Cosmetic Science – https://doi.org/10.1111/ics.12681

·        Oral HA improves wrinkle depth and skin moisture (2012) – Clin Interv Aging – https://pubmed.ncbi.nlm.nih.gov/22165012/

·        HA oral administration and skin texture in aging skin (2016) – J Cosmet Dermatol – https://doi.org/10.1111/jocd.12451

·        HA capsules reduce wrinkle depth in Japanese women (2020) – J Cosmet Dermatol – https://doi.org/10.1111/jocd.12813

Coenzyme Q10 (CoQ10)

·        CoQ10 improves endothelial function in older adults (2006) – Nutrition, Metabolism and Cardiovascular Diseases – https://doi.org/10.1016/j.numecd.2006.02.005

·        CoQ10 supplementation improves energy and quality of life in elderly (2005) – JACC – https://doi.org/10.1016/j.jacc.2004.11.039

·        CoQ10 reduces oxidative stress markers in aging populations (2020) – GeroScience – https://doi.org/10.1007/s11357-020-00186-2

·        CoQ10 and selenium improve cardiovascular mortality in elderly (2014) – PLOS One – https://doi.org/10.1371/journal.pone.0102343

·        CoQ10 supplementation improves fatigue and physical performance in aging adults (2017) – Geriatrics & Gerontology International – https://doi.org/10.1111/ggi.13113

Collagen Peptides

·        Oral collagen peptides improve skin elasticity and moisture retention (2014) – Skin Pharmacol Physiol – https://doi.org/10.1159/000351376

·        Collagen peptides increase dermal density in middle-aged women (2015) – J Cosmet Dermatol – https://doi.org/10.1111/jocd.12174

·        Oral collagen improves skin appearance and hydration (2015) – J Nutr Biochem – https://doi.org/10.1016/j.jnutbio.2014.10.001

·        Collagen hydrolysate reduces joint pain in aging athletes (2008) – Curr Ther Res – https://doi.org/10.1016/j.curtheres.2008.09.006

·        Oral collagen improves nail health in mature women (2020) – J Cosmet Dermatol – https://doi.org/10.1111/jocd.13490

 

Niagen (Nicotinamide Riboside)

·        NR supplementation raises NAD⁺ in healthy older adults (2016) – Nature Communications – https://doi.org/10.1038/ncomms12948

·        NR improves vascular function in aging humans (2018) – Nature Medicine – https://doi.org/10.1038/s41591-018-0089-9

·        NR enhances muscle regeneration and mitochondrial biogenesis (2020) – Cell – https://doi.org/10.1016/j.cell.2020.07.038

·        NR reduces inflammation and oxidative stress in older adults (2021) – Clinical Nutrition – https://doi.org/10.1016/j.clnu.2021.01.008

·        NR administration enhances NAD+ metabolism in prediabetic elderly (2020) – Nature Medicine – https://doi.org/10.1038/s41591-020-0941-1

Curcumin

·        Curcumin improves memory and attention in elderly population (2018) – American Journal of Medicine – https://doi.org/10.1016/j.amjmed.2018.10.014

·        Curcumin reduces systemic inflammation in aging adults (2016) – Journal of Psychiatric Research – https://doi.org/10.1016/j.jpsychires.2016.07.013

·        Bioavailable curcumin supports cognitive function in humans (2021) – Journal of Affective Disorders – https://doi.org/10.1016/j.jad.2021.05.009

·        Curcumin improves endothelial function in healthy elderly (2014) – Clinical Therapeutics – https://doi.org/10.1016/j.clinthera.2014.02.012

·        Curcumin as an adjunct in depressive symptoms in aged adults (2015) – Journal of Psychosomatic Research – https://doi.org/10.1016/j.jpsychores.2015.03.002

Vitamin D

·        Vitamin D supplementation reduces fall risk in elderly (2006) – JAMA – https://doi.org/10.1001/jama.295.24.2865

·        Vitamin D improves muscle strength and balance in older adults (2013) – Maturitas – https://doi.org/10.1016/j.maturitas.2013.05.005

·        Vitamin D associated with lower all-cause mortality (2014) – The Lancet – https://doi.org/10.1016/S0140-6736(14)60961-5

·        Vitamin D supplementation and telomere length in aging adults (2017) – J Gerontol A Biol Sci Med Sci – https://doi.org/10.1093/gerona/glx058

·        Vitamin D supplementation improves sleep quality in older people (2018) – Sleep Medicine – https://doi.org/10.1016/j.sleep.2018.11.011

Vitamin E

·        Vitamin E enhances immune response in elderly (2004) – The Journal of Nutrition – https://doi.org/10.1093/jn/134.7.1803S

·        Vitamin E improves oxidative stress markers in aging population (2001) – BBRC – https://doi.org/10.1016/S0006-291X(01)00699-8

·        Vitamin E supplementation supports skin aging prevention (2007) – Journal of Nutritional Biochemistry – https://doi.org/10.1016/j.jnutbio.2007.01.001

·        Vitamin E reduces cognitive decline in elderly with mild Alzheimer’s (2005) – JAMA – https://doi.org/10.1001/jama.2005.1923

·        Vitamin E combined with C improves skin photoprotection in humans (2002) – JAAD – https://doi.org/10.1016/j.jaad.2002.12.008